HBOT in DFU Treatment: Pressure still on to find compelling evidence for widespread use

October 20, 2017

October 16, 2017

 

Efficacy of Hyperbaric Oxygen Therapy in Diabetic Foot Ulcers

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Researchers evaluated the efficacy and safety profile of using hyperbaric oxygen therapy for the treatment of diabetic foot ulcers.Researchers evaluated the efficacy and safety profile of using hyperbaric oxygen therapy for the treatment of diabetic foot ulcers.

The use of hyperbaric oxygen therapy (HBOT) in the treatment of diabetic foot ulcers may not result in a difference in outcomes when compared with standard therapy (ST), according to a study published by Clinical Therapeutics.

Researchers performed a meta-analysis of 9 randomized controlled trials including 526 patients to determine the efficacy and safety profile of using HBOT as a treatment modality in patients with diabetic foot ulcers, with a focus on the “incidence of healed ulcers, major amputations, minor amputations and reduction in the ulcer wound area.”

 

There were no differences identified between patients treated with HBOT compared with ST with regard to the incidence of healed ulcers (risk ratio [RR] = 2.22, 95% CI, 0.87-5.62; P =.32; I2 = 81%), minor amputations (RR = .95; 95% CI, 0.39-2.29; P =.91; I2 = 74%), major amputations (RR = .47; 95% CI, 0.17-1.28; P =.14; I2 = 61%), and adverse events (RR = 1.00; 95% CI, 0.64-1.56; P=.99; I2 = 26%). However, it was found that HBOT resulted in a statistically significant greater reduction in ulcer wound area when compared with ST (standard mean difference = 1.12; 95% CI, 0.20-2.04; P =.04; I2 = 70%).

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